Could hallucinogens induce permanent pupillary changes in (ab)users? A case report from New Zealand. You can learn more about how we ensure our content is accurate and current by reading our editorial policy. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. call 911 immediately if you notice someone who has pinpoint pupils. This is a sign of an opioid overdose, which is a medical emergency. Pinpoint pupils are pupils that do not respond to changes in lighting. Opioids, including oxycodone, heroin, and fentanyl, are commonly misused drugs that have the opposite effect, causing pupils to constrict (miosis). Commonly misused drugs that dilate the pupils include: They’re the most commonly prescribed treatment for depression.ĭilated pupils are sometimes a sign of drug misuse. SSRIs enhance the effects of serotonin in the brain. Selective serotonin reuptake inhibitors (SSRIs)ĭepression, anxiety, post-traumatic stress disorder (PTSD) Both Ritalin and Adderall cause pupils to dilate. Stimulants, such as Ritalin and Adderall, are common in the treatment of attention-deficit hyperactivity disorder (ADHD). Sometimes called eye dilation drops, they’re commonly used during eye exams and surgeries.Īttention-deficit hyperactivity disorder (ADHD) Mydriatics are a class of drugs that cause pupil dilation. Parkinson’s disease and other movement disordersĭopamine precursors, such as Levodopa, help to increase synthesis of the neurotransmitter dopamine. Benadryl is a common OTC antihistamine.īenzodiazepines enhance the effects of a neurotransmitter called GABA, which relaxes the muscles.ĭecongestants shrink the blood vessels in the nose, helping to treat swelling, inflammation, and mucus buildup.

Tricyclic antidepressants (TCAs) affect serotonin and norepinephrine, two chemical messengers that influence an extensive range of bodily functions.Īntihistamines block the action of histamine, an immune system chemical that triggers allergy symptoms, such as itchiness, a runny nose, and swelling. They include barbiturates like phenobarbital. Chronic obstructive pulmonary disorder (COPD), nausea, motion sickness, overactive bladder (OAB), urinary incontinence (UI)Īnticholinergics block the action of the acetylcholine, a neurotransmitter involved in muscle contractions.Īntiepileptics work by impacting neurotransmitter activity or nerve impulses in the brain.

Eye pupil dilation drugs